Anemia Comprehensive Panel
(such as sickle cell disease or thalassemia)
Anemia Comprehensive Panel
An anemia comprehensive panel is a group of blood tests used to determine whether anemia is present and identify the underlying cause. Test included in panel includes:
1. Complete Blood Count (CBC)
Evaluates the overall health of blood cells:
Hemoglobin (Hgb): Measures the oxygen-carrying protein; low levels indicate anemia.
Hematocrit (Hct): Measures the percentage of blood made up of red blood cells.
Red Blood Cell Count (RBC): Measures the number of red blood cells.
MCV (Mean Corpuscular Volume): Shows the size of red blood cells and helps classify anemia:
Low MCV → often iron deficiency
High MCV → often B12 or folate deficiency
MCH/MCHC: Measure the amount and concentration of hemoglobin inside red blood cells.
RDW: Shows variation in red blood cell size.
Platelets and White Blood Cells: Help evaluate other blood abnormalities.
2. Iron Studies
Used to evaluate iron levels and iron storage:
Serum Iron: Amount of iron circulating in the blood.
Ferritin: Measures stored iron; often the best indicator of iron deficiency.
Total Iron-Binding Capacity (TIBC): Measures how well the blood can transport iron.
Transferrin Saturation: Shows the percentage of transferrin carrying iron.
3. Vitamin Levels
Helps identify vitamin-related anemia:
Vitamin B12: Low levels can cause large red blood cells and nerve-related symptoms.
Folate (Vitamin B9): Needed for normal red blood cell production.
4. Reticulocyte Count
Measures immature red blood cells produced by the bone marrow.
High reticulocyte count may indicate the body is replacing lost blood (such as after bleeding).
Low reticulocyte count may suggest reduced red blood cell production.
5. Additional Tests Included
Depending on symptoms and initial results, providers may add:
Peripheral Blood Smear: Examines the appearance of blood cells under a microscope.
LDH (Lactate Dehydrogenase): May increase with red blood cell destruction.
Bilirubin: May be elevated when red blood cells are breaking down.
Haptoglobin: Helps detect hemolytic anemia (anemia caused by red blood cell destruction).
Comprehensive Metabolic Panel (CMP): Evaluates kidney and liver function, which can affect blood production.
Thyroid tests (TSH): Thyroid disorders can contribute to anemia.
Sample needed
Sample: A venous blood sample (blood drawn from a vein, usually in the arm).
What an anemia panel can help determine
An anemia panel can help identify whether anemia is caused by:
Iron deficiency
Vitamin B12 or folate deficiency
Blood loss
Chronic disease
Kidney problems
Increased breakdown of red blood cells
Bone marrow production problems

