The ceruloplasmin test is a blood test that measures the level of ceruloplasmin, a protein made by the liver that carries copper through the bloodstream. It is mainly used to evaluate copper metabolism and help diagnose certain liver and neurological conditions.

What the ceruloplasmin test measures

• Ceruloplasmin levels in the blood

• Helps assess how the body transports and regulates copper

What the test can help diagnose or evaluate

The ceruloplasmin test is most commonly used to help diagnose:

• Wilson disease

  • A rare inherited disorder where the body cannot properly remove excess copper.

  • Copper can build up in the liver, brain, and other organs.

  • Often associated with low ceruloplasmin levels and abnormal copper levels.

It may also be used when evaluating:

• Unexplained liver disease

• Abnormal liver function tests

• Neurological symptoms with unclear causes

• Abnormal copper levels

What abnormal results may mean

Low ceruloplasmin levels may be seen with:

• Wilson disease

• Severe liver disease

• Certain nutritional deficiencies

• Conditions affecting protein production

High ceruloplasmin levels may be seen with:

• Inflammation or infection

• Pregnancy

• Use of estrogen-containing medications

• Some cancers or autoimmune conditions

Related tests often ordered with ceruloplasmin

To better evaluate copper balance, providers may also order:

• Serum copper

• 24-hour urine copper test

• Liver function tests (LFTs)

• Genetic testing for Wilson disease (when appropriate)

• Liver imaging or biopsy in certain cases